Direct N9-arylation of purines with aryl halides.
نویسندگان
چکیده
An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(i) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N(9)-position.
منابع مشابه
Direct N-arylation of purines with aryl halides†
Purine is a ubiquitous heterocyclic scaffold of fundamental importance, and is considered to be a privileged structure in medicinal chemistry. Purine-based compounds, including N-aryl purines, exhibit a wide range of biological and pharmaceutical activities, such as antiviral, antibacterial and anticancer effects. In light of their importance, there is a surprising paucity of efficient methods ...
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 39 شماره
صفحات -
تاریخ انتشار 2014